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Warwick

24 December 2012   //   by admin   //   News  //  Comments Off

The majority of therapeutics clinically available for cancer treatment are platinum-based and work via a DNA alkylation mechanism that leads to cell apoptosis.  But a number of cancers are resistant to apoptosis and not treatable with platinum-based drugs.

In this paper Peter Sadler (University of Warwick), Steve Shnyder (University of Bradford) and teams have developed an organometallic half-sandwich osmium complex that displays significant anti-cancer activity with negligible toxicity in vivo. Osmium is also a platinum group metal but has a completely different mode of action and appears to operate via redox mechanisms – making these complexes candidates for further investigation and potentially clinical trials.

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